Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity

Dysregulated Foxp3(+) Treg functions result in uncontrolled immune activation and autoimmunity. Therefore, identifying cellular factors modulating Treg functions is an area of great importance. Here, using Treg-specific Il27ra(−/−) mice, we report that IL-27 signaling in Foxp3(+) Tregs is essential...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Do, Jeongsu, Kim, Dongkyun, Kim, Sohee, Valentin-Torres, Alice, Dvorina, Nina, Jang, Eunjung, Nagarajavel, Vivekananthan, DeSilva, Tara M., Li, Xiaoxia, Ting, Angela H., Vignali, Dario A. A., Stohlman, Stephen A., Baldwin, William M., Min, Booki
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617261/
https://ncbi.nlm.nih.gov/pubmed/28874534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703100114
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