Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Cli...

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Bibliografiska uppgifter
Huvudupphovsmän: Curtin, James F., Candolfi, Marianela, Fakhouri, Tamer M., Liu, Chunyan, Alden, Anderson, Edwards, Matthew, Lowenstein, Pedro R., Castro, Maria G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291560/
https://ncbi.nlm.nih.gov/pubmed/18431473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001983
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