Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Cli...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Curtin, James F., Candolfi, Marianela, Fakhouri, Tamer M., Liu, Chunyan, Alden, Anderson, Edwards, Matthew, Lowenstein, Pedro R., Castro, Maria G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2008
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291560/
https://ncbi.nlm.nih.gov/pubmed/18431473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001983
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