Gene Therapy-Mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model

Immune-mediated gene therapy using adenovirus expressing Flt3 ligand and thymidine kinase followed by ganciclovir administration (Flt3/TK) effectively elicits tumor regression in preclinical glioma models. Herein, we assessed new strategies to optimize Flt3L/TK therapeutic efficacy in a refractory R...

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Bibliografiske detaljer
Main Authors: Mineharu, Yohei, Muhammad, AKM Ghulam, Yagiz, Kader, Candolfi, Marianela, Kroeger, Kurt M., Xiong, Weidong, Puntel, Mariana, Liu, Chunyan, Levy, Eva, Lugo, Claudia, Kocharian, Adrina, Allison, James P., Curran, Michael A., Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2012
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480576/
https://ncbi.nlm.nih.gov/pubmed/22996231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-012-0144-7
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