Gene Therapy-Mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model

Immune-mediated gene therapy using adenovirus expressing Flt3 ligand and thymidine kinase followed by ganciclovir administration (Flt3/TK) effectively elicits tumor regression in preclinical glioma models. Herein, we assessed new strategies to optimize Flt3L/TK therapeutic efficacy in a refractory R...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Mineharu, Yohei, Muhammad, AKM Ghulam, Yagiz, Kader, Candolfi, Marianela, Kroeger, Kurt M., Xiong, Weidong, Puntel, Mariana, Liu, Chunyan, Levy, Eva, Lugo, Claudia, Kocharian, Adrina, Allison, James P., Curran, Michael A., Lowenstein, Pedro R., Castro, Maria G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer-Verlag 2012
Onderwerpen:
Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480576/
https://ncbi.nlm.nih.gov/pubmed/22996231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-012-0144-7
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items