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Conversion of agonist site to metal-ion chelator site in the β(2)-adrenergic receptor

Previously metal-ion sites have been used as structural and functional probes in seven transmembrane receptors (7TM), but as yet all the engineered sites have been inactivating. Based on presumed agonist interaction points in transmembrane III (TM-III) and -VII of the β(2)-adrenergic receptor, in th...

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Autors principals: Elling, Christian E., Thirstrup, Kenneth, Holst, Birgitte, Schwartz, Thue W.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC22915/
https://ncbi.nlm.nih.gov/pubmed/10535920
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