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STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

LKB1, a serine/threonine kinase, regulates cell polarity, metabolism, and cell growth. The activity and cellular distribution of LKB1 are determined by cofactors, STRADα and MO25. STRADα induces relocalization of LKB1 from the nucleus to the cytoplasm and stimulates its catalytic activity. MO25 stab...

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Bibliografiske detaljer
Main Authors: Dorfman, Julia, Macara, Ian G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291406/
https://ncbi.nlm.nih.gov/pubmed/18256292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-05-0454
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