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Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters

The organization of Ras proteins into nanoclusters on the inner plasma membrane is essential for Ras signal transduction, but the mechanisms that drive nanoclustering are unknown. Here we show that epidermal growth factor receptor activation stimulates the formation of H-Ras.GTP-Galectin-1 (Gal-1) c...

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Détails bibliographiques
Auteurs principaux: Belanis, Liron, Plowman, Sarah J., Rotblat, Barak, Hancock, John F., Kloog, Yoel
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291398/
https://ncbi.nlm.nih.gov/pubmed/18234837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-10-1053
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