H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK. The specificity and magnitude of downstream activation is achieved by the spatio-temporal organization of the active H-Ras in the plasma membrane. Upon activation, the G...

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Bibliographic Details
Main Authors:	Rotblat, Barak, Belanis, Liron, Liang, Hong, Haklai, Roni, Elad-Zefadia, Galit, Hancock, John F., Kloog, Yoel, Plowman, Sarah J.
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2010
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2916832/ https://ncbi.nlm.nih.gov/pubmed/20700538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011991
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H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output

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