Individual Palmitoyl Residues Serve Distinct Roles in H-Ras Trafficking, Microlocalization, and Signaling

H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181 and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester. Here we demonstrate that the two palmitates serve distinct biological roles. Monopalmitoylation of Cys181 is required and...

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Bibliografiske detaljer
Main Authors: Roy, Sandrine, Plowman, Sarah, Rotblat, Barak, Prior, Ian A., Muncke, Cornelia, Grainger, Sarah, Parton, Robert G., Henis, Yoav I., Kloog, Yoel, Hancock, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190337/
https://ncbi.nlm.nih.gov/pubmed/16024806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6722-6733.2005
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