In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease

AIMS: The aims of this study were to visualize in vivo binding of donepezil to acetylcholinesterase (AChE) in the brain and to establish a method for measuring the amount of binding of orally administered donepezil. METHODS: [5-(11)C-methoxy]-donepezil ([(11)C]-donepezil) was radiolabelled as a posi...

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Bibliografske podrobnosti
Main Authors: Okamura, Nobuyuki, Funaki, Yoshihito, Tashiro, Manabu, Kato, Motohisa, Ishikawa, Yoichi, Maruyama, Masahiro, Ishikawa, Hiroyasu, Meguro, Kenichi, Iwata, Ren, Yanai, Kazuhiko
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2008
Teme:
Pharmacodynamics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291371/
https://ncbi.nlm.nih.gov/pubmed/18070217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.03063.x
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