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DESCENDING SEROTONERGIC FACILITATION OF SPINAL ERK ACTIVATION AND PAIN BEHAVIOR
Serotonin (5-HT) derived from bulbo-spinal projection is released by nociceptive input into the spinal dorsal horn. Here we report that formalin injection in the paw produced pain behavior (flinching) and phosphorylation of spinal ERK1/2 (P-ERK1/2, indicating activation) in rats. Depletion of spinal...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2291024/ https://ncbi.nlm.nih.gov/pubmed/17113581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2006.11.012 |
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