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Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain
BACKGROUND: Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal horn neurones in a neuropathic pain model, and shown this to...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744671/ https://ncbi.nlm.nih.gov/pubmed/19664204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-45 |
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