Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain

BACKGROUND: Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal horn neurones in a neuropathic pain model, and shown this to...

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Autors principals: Rahman, Wahida, Bauer, Claudia S, Bannister, Kirsty, Vonsy, Jean-Laurent, Dolphin, Annette C, Dickenson, Anthony H
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744671/
https://ncbi.nlm.nih.gov/pubmed/19664204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-45
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