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X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations
X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-linked genes in female cells. We report that subcultures from lines of female human embryonic stem cells (hESCs) exhibit variation (0–100%) for XCI markers, including XIST RNA expression and enrichment of histone...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290804/ https://ncbi.nlm.nih.gov/pubmed/18339804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712018105 |
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