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X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC) have generated enormous interest as agents of cell replacement therapy. One potential limitation is their safety in vivo. Although several studies have focused on concerns over genomic stability ex vivo, few...

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Hlavní autoři: Silva, Susana S., Rowntree, Rebecca K., Mekhoubad, Shila, Lee, Jeannie T.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290799/
https://ncbi.nlm.nih.gov/pubmed/18339803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712136105
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