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X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells

With the potential to give rise to all somatic cell types, human embryonic stem cells (hESC) have generated enormous interest as agents of cell replacement therapy. One potential limitation is their safety in vivo. Although several studies have focused on concerns over genomic stability ex vivo, few...

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Detalhes bibliográficos
Main Authors: Silva, Susana S., Rowntree, Rebecca K., Mekhoubad, Shila, Lee, Jeannie T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290799/
https://ncbi.nlm.nih.gov/pubmed/18339803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712136105
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