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Epigenetic stability, adaptability, and reversibility in human embryonic stem cells

The stability of human embryonic stem cells (hESCs) is of critical importance for both experimental and clinical applications. We find that as an initial response to altered culture conditions, hESCs change their transcription profile for hundreds of genes and their DNA methylation profiles for seve...

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Autores principales: Tompkins, Joshua D., Hall, Christine, Chen, Vincent Chang-yi, Li, Arthur Xuejun, Wu, Xiwei, Hsu, David, Couture, Larry A., Riggs, Arthur D.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411986/
https://ncbi.nlm.nih.gov/pubmed/22802633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209620109
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