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Epigenetic stability, adaptability, and reversibility in human embryonic stem cells

The stability of human embryonic stem cells (hESCs) is of critical importance for both experimental and clinical applications. We find that as an initial response to altered culture conditions, hESCs change their transcription profile for hundreds of genes and their DNA methylation profiles for seve...

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Detalhes bibliográficos
Main Authors: Tompkins, Joshua D., Hall, Christine, Chen, Vincent Chang-yi, Li, Arthur Xuejun, Wu, Xiwei, Hsu, David, Couture, Larry A., Riggs, Arthur D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411986/
https://ncbi.nlm.nih.gov/pubmed/22802633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209620109
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