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Epigenetic stability, adaptability, and reversibility in human embryonic stem cells

The stability of human embryonic stem cells (hESCs) is of critical importance for both experimental and clinical applications. We find that as an initial response to altered culture conditions, hESCs change their transcription profile for hundreds of genes and their DNA methylation profiles for seve...

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Autors principals: Tompkins, Joshua D., Hall, Christine, Chen, Vincent Chang-yi, Li, Arthur Xuejun, Wu, Xiwei, Hsu, David, Couture, Larry A., Riggs, Arthur D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411986/
https://ncbi.nlm.nih.gov/pubmed/22802633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209620109
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