X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-linked genes in female cells. We report that subcultures from lines of female human embryonic stem cells (hESCs) exhibit variation (0–100%) for XCI markers, including XIST RNA expression and enrichment of histone...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shen, Yin, Matsuno, Youko, Fouse, Shaun D., Rao, Nagesh, Root, Sierra, Xu, Renhe, Pellegrini, Matteo, Riggs, Arthur D., Fan, Guoping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290804/
https://ncbi.nlm.nih.gov/pubmed/18339804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712018105
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