Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, Polycomb binding and histone H3 lys4/lys27 trimethylation

We report here genome-wide mapping of DNA methylation patterns at proximal promoter regions in mouse embryonic stem cells (mESCs). Most methylated genes are differentiation-associated and repressed in mESCs. By contrast, the unmethylated gene set includes many housekeeping and pluripotency genes. By...

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Main Authors: Fouse, Shaun D., Shen, Yin, Pellegrini, Matteo, Cole, Steve, Meissner, Alexander, Van Neste, Leander, Jaenisch, Rudolf, Fan, Guoping
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070208/
https://ncbi.nlm.nih.gov/pubmed/18371437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2007.12.011
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