Hyperconserved CpG domains underlie Polycomb-binding sites

Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases in vertebrate genomes, has been constrained by their evolutionary instability and by the effect of methylation on their mutation rates. We compared the human and chimpanzee genomes to identify DNA sequence signatu...

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Bibliografske podrobnosti
Main Authors: Tanay, Amos, O'Donnell, Anne H., Damelin, Marc, Bestor, Timothy H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838490/
https://ncbi.nlm.nih.gov/pubmed/17376869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609746104
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