Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1 and Polycomb Members to Promoter CpG Islands

Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by treatment with hydrogen peroxide, recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes part of a complex(es) containing DNMT3B and members...

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Autori principali: O’Hagan, Heather M., Wang, Wei, Sen, Subhojit, Shields, Christina DeStefano, Lee, Stella S., Zhang, Yang W., Clements, Eriko G., Cai, Yi, Van Neste, Leander, Easwaran, Hariharan, Casero, Robert A., Sears, Cynthia L., Baylin, Stephen B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220885/
https://ncbi.nlm.nih.gov/pubmed/22094255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.012
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