Allosteric modulation of the mouse kir6.2 channel by intracellular H(+) and ATP

The ATP-sensitive K(+) (K(ATP)) channels are regulated by intracellular H(+) in addition to ATP, ADP, and phospholipids. Here we show evidence for the interaction of H(+) with ATP in regulating a cloned K(ATP) channel, i.e. Kir6.2 expressed with and without the SUR1 subunit. Channel sensitivity to A...

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Detalhes bibliográficos
Main Authors: Wu, Jianping, Cui, Ningren, Piao, Hailan, Wang, Ying, Xu, Haoxing, Mao, Jinzhe, Jiang, Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290504/
https://ncbi.nlm.nih.gov/pubmed/12205184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.025247
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