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Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?
Chemical modification can inhibit ion channels either by reacting with pore-lining residues and directly occluding the channel or by closing the channel allosterically. A general method to distinguish between these two mechanisms does not exist. Previously, sulfhydryl (SH) modification has been show...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290265/ https://ncbi.nlm.nih.gov/pubmed/11986364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.013366 |
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