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Mutation of Walker-A lysine 464 in cystic fibrosis transmembrane conductance regulator reveals functional interaction between its nucleotide-binding domains
The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel bears two nucleotide-binding domains (NBD1 and NBD2) that control its ATP-dependent gating. Exactly how these NBDs control gating is controversial. To address this issue, we examined channels with a Walker-A lysine mutat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2290141/ https://ncbi.nlm.nih.gov/pubmed/11882668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2001.013162 |
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