Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized that their detection by DCs may involve the endosomal DNA recognition receptor TLR9....

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Bibliographische Detailangaben
Hauptverfasser: Samuelsson, Christofer, Hausmann, Jürgen, Lauterbach, Henning, Schmidt, Michaela, Akira, Shizuo, Wagner, Hermann, Chaplin, Paul, Suter, Mark, O’Keeffe, Meredith, Hochrein, Hubertus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289795/
https://ncbi.nlm.nih.gov/pubmed/18398511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33940
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