Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

Poxviruses such as the causative agent of smallpox have developed multiple strategies to suppress immune responses, including the suppression of DC activation. Since poxviruses are large DNA viruses, we hypothesized that their detection by DCs may involve the endosomal DNA recognition receptor TLR9....

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Bibliographic Details
Main Authors: Samuelsson, Christofer, Hausmann, Jürgen, Lauterbach, Henning, Schmidt, Michaela, Akira, Shizuo, Wagner, Hermann, Chaplin, Paul, Suter, Mark, O’Keeffe, Meredith, Hochrein, Hubertus
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289795/
https://ncbi.nlm.nih.gov/pubmed/18398511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33940
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