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Dihydrofolate reductase gene amplification-associated shift of differentiation in methotrexate-adapted HT-29 cells

Postconfluent cultures of HT-29 cells form a heterogeneous multilayer of which greater than 95% of the cells are undifferentiated. In contrast, when stably adapted to normally lethal concentrations of methotrexate (10(-6)-10(-5) M), they form a monolayer of gobletlike cells (Lesuffleur et al., 1990)...

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Bibliografski detalji
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1991
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2289245/
https://ncbi.nlm.nih.gov/pubmed/1955481
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