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A novel and conserved pocket of human κ-Fab fragments: Design, synthesis, and verification of directed affinity ligands
Antibodies of type IgG may be divided into two classes, called λor κ, depending on the type of light chain. We have identified a conserved pocket between the two domains CH1 and CL of human IgG κ-Fab, which is not present in the λ type. This pocket was used as a target docking site with the purpose...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2279986/ https://ncbi.nlm.nih.gov/pubmed/15152083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04687404 |
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