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A novel and conserved pocket of human κ-Fab fragments: Design, synthesis, and verification of directed affinity ligands

Antibodies of type IgG may be divided into two classes, called λor κ, depending on the type of light chain. We have identified a conserved pocket between the two domains CH1 and CL of human IgG κ-Fab, which is not present in the λ type. This pocket was used as a target docking site with the purpose...

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Autores principales: Carredano, Enrique, Baumann, Herbert, Grönberg, Anna, Norrman, Nils, Glad, Gunnar, Zou, Jinyu, Ersoy, Oguz, Steensma, Elles, Axén, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279986/
https://ncbi.nlm.nih.gov/pubmed/15152083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04687404
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