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Rational design, synthesis, and verification of affinity ligands to a protein surface cleft
The structure-based design, synthesis, and screening of a glucuronic acid scaffold library of affinity ligands directed toward the catalytic cleft on porcine pancreas α-amylase are presented. The design was based on the simulated docking to the enzyme active site of 53 aryl glycosides from the Avail...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Cold Spring Harbor Laboratory Press
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2323846/ https://ncbi.nlm.nih.gov/pubmed/12649437 |
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