Somatostatin inhibits exocytosis in rat pancreatic α-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules

1. Measurements of cell capacitance were used to investigate the molecular mechanisms by which somatostatin inhibits Ca(2+)-induced exocytosis in single rat glucagon-secreting pancreatic α-cells. 2. Somatostatin decreased the exocytotic responses elicited by voltage-clamp depolarisations by 80 % in...

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Bibliografiska uppgifter
Huvudupphovsmän: Gromada, Jesper, Høy, Marianne, Buschard, Karsten, Salehi, Albert, Rorsman, Patrik
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2001
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278803/
https://ncbi.nlm.nih.gov/pubmed/11533141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.00519.x
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