Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Insulin secretion is controlled by the β cell′s metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on...

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Detalhes bibliográficos
Main Authors: Olsen, Hervør L., Høy, Marianne, Zhang, Wei, Bertorello, Alejandro M., Bokvist, Krister, Capito, Kirsten, Efanov, Alexander M., Meister, Björn, Thams, Peter, Yang, Shao-Nian, Rorsman, Patrik, Berggren, Per-Olof, Gromada, Jesper
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154320/
https://ncbi.nlm.nih.gov/pubmed/12700357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931282100
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