Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Insulin secretion is controlled by the β cell′s metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Olsen, Hervør L., Høy, Marianne, Zhang, Wei, Bertorello, Alejandro M., Bokvist, Krister, Capito, Kirsten, Efanov, Alexander M., Meister, Björn, Thams, Peter, Yang, Shao-Nian, Rorsman, Patrik, Berggren, Per-Olof, Gromada, Jesper
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 2003
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12700357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0931282100
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