Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Insulin secretion is controlled by the β cell′s metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Olsen, Hervør L., Høy, Marianne, Zhang, Wei, Bertorello, Alejandro M., Bokvist, Krister, Capito, Kirsten, Efanov, Alexander M., Meister, Björn, Thams, Peter, Yang, Shao-Nian, Rorsman, Patrik, Berggren, Per-Olof, Gromada, Jesper
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2003
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12700357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0931282100
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!