Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K(+) (K(ATP)) conductance in rat pancreatic A-cells

1. Capacitance measurements were used to examine the effects of the sulphonylurea tolbutamide on Ca(2+)-dependent exocytosis in isolated glucagon-secreting rat pancreatic A-cells. 2. When applied extracellularly, tolbutamide stimulated depolarization-evoked exocytosis 4.2-fold without affecting the...

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Detalhes bibliográficos
Main Authors: Høy, Marianne, Olsen, Hervør L, Bokvist, Krister, Buschard, Karsten, Barg, Sebastian, Rorsman, Patrik, Gromada, Jesper
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270047/
https://ncbi.nlm.nih.gov/pubmed/10944174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00109.x
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