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Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K(+) (K(ATP)) conductance in rat pancreatic A-cells
1. Capacitance measurements were used to examine the effects of the sulphonylurea tolbutamide on Ca(2+)-dependent exocytosis in isolated glucagon-secreting rat pancreatic A-cells. 2. When applied extracellularly, tolbutamide stimulated depolarization-evoked exocytosis 4.2-fold without affecting the...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2270047/ https://ncbi.nlm.nih.gov/pubmed/10944174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00109.x |
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