CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells

1. Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca(2+)-induced exocytosis in single insulin-secreting mouse pancreatic B-cells. 2. ACh (250 μM) increased exocytotic responses elicited by voltage-clamp depolarizations 2.3-fold. This...

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Autori principali: Gromada, Jesper, Høy, Marianne, Renström, Erik, Bokvist, Krister, Eliasson, Lena, Göpel, Sven, Rorsman, Patrik
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 1999
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269462/
https://ncbi.nlm.nih.gov/pubmed/10420011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.0745p.x
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