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Two open states and rate-limiting gating steps revealed by intracellular Na(+) block of human KCNQ1 and KCNQ1/KCNE1 K(+) channels
1. KCNQ1, the first member of a new K(+) channel family, associates with the small KCNE1 subunit to form the slow cardiac delayed rectifier current, I(Ks). Mutations in both genes encoding these channels lead to cardiac arrhythmia. We studied the block by intracellular Na(+) of human homomeric KCNQ1...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278592/ https://ncbi.nlm.nih.gov/pubmed/11351022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0135b.x |
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