Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the α subunit

1. Neurosteroids are produced in the brain, and can have rapid actions on membrane channels of neurons. Pregnenolone sulfate (PS) is a sulfated neurosteroid which reduces the responses of the γ-aminobutyric acid A (GABAA) receptor. We analysed the actions of PS on single-channel currents from recomb...

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Bibliographic Details
Main Authors: Akk, Gustav, Bracamontes, John, Steinbach, Joe Henry
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2001
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2278584/
https://ncbi.nlm.nih.gov/pubmed/11313438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2001.0673e.x
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