MgATP activates the β cell K(ATP )channel by interaction with its SUR1 subunit

ATP-sensitive potassium (K(ATP)) channels in the pancreatic β cell membrane mediate insulin release in response to elevation of plasma glucose levels. They are open at rest but close in response to glucose metabolism, producing a depolarization that stimulates Ca(2+) influx and exocytosis. Metabolic...

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Hauptverfasser: Gribble, Fiona M., Tucker, Stephen J., Haug, Trude, Ashcroft, Frances M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22779/
https://ncbi.nlm.nih.gov/pubmed/9618560
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