Bloom’s syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

Perturbed DNA replication either activates a cell cycle checkpoint, which halts DNA replication, or decreases the rate of DNA synthesis without activating a checkpoint. Here we report that at low doses, replication inhibitors did not activate a cell cycle checkpoint, but they did activate a process...

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Main Authors: Shimura, Tsutomu, Torres, Michael J., Martin, Melvenia M., Rao, V. Ashutosh, Pommier, Yves, Katsura, Mari, Miyagawa, Kiyoshi, Aladjem, Mirit I.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276852/
https://ncbi.nlm.nih.gov/pubmed/18054789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.006
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