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The structure-specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

Repair of interstrand crosslinks (ICLs) requires multiple-strand incisions to separate the two covalently attached strands of DNA. It is unclear how these incisions are generated. DNA double-strand breaks (DSBs) have been identified as intermediates in ICL repair, but enzymes responsible for produci...

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Detalhes bibliográficos
Main Authors: Hanada, Katsuhiro, Budzowska, Magda, Modesti, Mauro, Maas, Alex, Wyman, Claire, Essers, Jeroen, Kanaar, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618088/
https://ncbi.nlm.nih.gov/pubmed/17036055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601344
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