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Development of a Rapid and Sensitive LC-MS/MS assay for the Determination of Sorafenib in Human Plasma

A rapid and sensitive liquid chromatography/tandem mass spectrometric (LC/MS/MS) assay was developed for the quantitative determination of sorafenib in human plasma. Sample pretreatment involved simple protein precipitation by the addition of 0.5 mL acetonitrile, containing internal standard ([(2)H(...

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Detalhes bibliográficos
Main Authors: Jain, Lokesh, Gardner, Erin R., Venitz, Jürgen, Dahut, William, Figg, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276641/
https://ncbi.nlm.nih.gov/pubmed/18309574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2007.10.027
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