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Development of a Rapid and Sensitive LC-MS/MS assay for the Determination of Sorafenib in Human Plasma
A rapid and sensitive liquid chromatography/tandem mass spectrometric (LC/MS/MS) assay was developed for the quantitative determination of sorafenib in human plasma. Sample pretreatment involved simple protein precipitation by the addition of 0.5 mL acetonitrile, containing internal standard ([(2)H(...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2276641/ https://ncbi.nlm.nih.gov/pubmed/18309574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2007.10.027 |
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