Population pharmacokinetic analysis of sorafenib in patients with solid tumours

AIMS: To characterize the pharmacokinetics (PK) of sorafenib in patients with solid tumours and to evaluate the possible effects of demographic, clinical and pharmacogenetic (CYP3A4*1B, CYP3A5*3C, UGT1A9*3 and UGT1A9*5) covariates on the disposition of sorafenib. METHODS: PK were assessed in 111 pat...

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Main Authors: Jain, Lokesh, Woo, Sukyung, Gardner, Erin R, Dahut, William L, Kohn, Elise C, Kummar, Shivaani, Mould, Diane R, Giaccone, Giuseppe, Yarchoan, Robert, Venitz, Jürgen, Figg, William D
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2011
Fag:
Uropharmacology Themed Section
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162659/
https://ncbi.nlm.nih.gov/pubmed/21392074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03963.x
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