Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma

Remdesivir, formerly GS-5734, has recently become the first antiviral drug approved by the U.S. Food and Drug Administration (FDA) to treat COVID-19, the disease caused by SARS-CoV-2. Therapeutic dosing and pharmacokinetic studies require a simple, sensitive, and selective validated assay to quantif...

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Udgivet i:J Chromatogr B Analyt Technol Biomed Life Sci
Main Authors: Nguyen, Ryan, Goodell, Jennifer C., Shankarappa, Priya S., Zimmerman, Sara, Yin, Tyler, Peer, Cody J., Figg, William D.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944857/
https://ncbi.nlm.nih.gov/pubmed/33756448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2021.122641
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