Development and validation of sensitive LC-MS/MS assays for quantification of HP-β-CD in human plasma and CSF

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD), a widely used excipient for drug formulation, has emerged as an investigational new drug for the treatment of Niemann-Pick type C1 (NPC1) disease, a neurodegenerative cholesterol storage disorder. Development of a sensitive quantitative LC-MS/MS assay to mon...

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Main Authors: Jiang, Hui, Sidhu, Rohini, Fujiwara, Hideji, De Meulder, Marc, de Vries, Ronald, Gong, Yong, Kao, Mark, Porter, Forbes D., Yanjanin, Nicole M., Carillo-Carasco, Nuria, Xu, Xin, Ottinger, Elizabeth, Woolery, Myra, Ory, Daniel S., Jiang, Xuntian
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Methods
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076072/
https://ncbi.nlm.nih.gov/pubmed/24868096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D050278
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