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A HILIC-MS/MS Method for Simultaneous Quantification of the Lysosomal Disease Markers Galactosylsphingosine and Glucosylsphingosine in Mouse Serum

Deficiencies of galactosylceramidase and glucocerebrosidase result in the accumulation of galactosylsphingosine (GalSph) and glucosylsphingosine (GluSph) in Krabbe and Gaucher diseases, respectively. GalSph and GluSph are useful biomarkers for both diagnosis and monitoring of treatment effects. We h...

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書誌詳細
出版年:Biomed Chromatogr
主要な著者: Sidhu, Rohini, Mikulka, Christina R., Fujiwara, Hideji, Sands, Mark S., Schaffer, Jean E., Ory, Daniel S., Jiang, Xuntian
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992066/
https://ncbi.nlm.nih.gov/pubmed/29516569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4235
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