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Mycobacterial PGL virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation

Phenolic glycolipids (PGLs) are polyketide-derived virulence factors produced by Mycobacterium tuberculosis, Mycobacterium leprae, and other mycobacterial pathogens. We have combined bioinformatic, genetic, biochemical, and chemical biology approaches to illuminate the mechanism of chain initiation...

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Bibliografiske detaljer
Main Authors: Ferreras, Julian A., Stirrett, Karen L., Lu, Xuequan, Ryu, Jae-Sang, Soll, Clifford E., Tan, Derek S., Quadri, Luis E. N.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276623/
https://ncbi.nlm.nih.gov/pubmed/18158259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.11.010
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