Identification of Phthiodiolone Ketoreductase, an Enzyme Required for Production of Mycobacterial Diacyl Phthiocerol Virulence Factors

Diacyl phthiocerol esters and their congeners are mycobacterial virulence factors. The biosynthesis of these complex lipids remains poorly understood. Insight into their biosynthesis will aid the development of rationally designed drugs that inhibit their production. In this study, we investigate a...

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Главные авторы: Onwueme, Kenolisa C., Vos, Cheryl J., Zurita, Juan, Soll, Clifford E., Quadri, Luis E. N.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2005
Предметы:
Molecular Biology of Pathogens
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1169502/
https://ncbi.nlm.nih.gov/pubmed/15995190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.14.4760-4766.2005
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