Flurazepam effect on GABAergic currents depends on extracellular pH

BACKGROUND AND PURPOSE: Benzodiazepines (BDZs) are widely used in clinical practice and are known as positive modulators of GABAergic currents. BDZs increase binding affinity and recently they were found to affect GABA(A) receptor gating, including desensitization. Binding and desensitization are al...

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Detalhes bibliográficos
Main Authors: Wójtowicz, T, Wyrembek, P, Lebida, K, Piast, M, Mozrzymas, J W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276312/
https://ncbi.nlm.nih.gov/pubmed/18362897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.90
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