Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons

BACKGROUND AND PURPOSE: Oenanthotoxin (OETX), a polyacetylenic alcohol from plants of the genus Oenanthe, has recently been identified as potent inhibitor of GABA-evoked currents. However, the effects of OETX on the inhibitory postsynaptic currents (IPSCs), as well as the pharmacological mechanism(s...

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Detalhes bibliográficos
Main Authors: Wyrembek, Paulina, Lebida, Katarzyna, Mercik, Katarzyna, Szczuraszek, Katarzyna, Szczot, Marcin, Pollastro, Federica, Appendino, Giovanni, Mozrzymas, Jerzy W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938803/
https://ncbi.nlm.nih.gov/pubmed/20590622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00644.x
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